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NasoNeb Provides Superior Deposition Compared to Traditional Spray Pumps

Spray bottles and rinses don't compare to the delivery efficiency of the NasoNeb® Sinus Therapy System

Overall the NNSTS has demonstrated potential to deliver medication to the turbinate region of the nasal model while at the same time minimizing potential lung deposition.

Nasal-Sprayed Particle Deposition Study Using the NasoNeb Sinus Therapy System and a Traditional Nasal Spray Pump

Science-based Evidence | April 5, 2020 

Spray bottles and rinses don't compare to the delivery efficiency of the NasoNeb® Sinus Therapy System

Overall the NNSTS has demonstrated potential to deliver medication to the turbinate region of the nasal model while at the same time minimizing potential lung deposition.

Introduction

Traditionally, nasal drug delivery has been used for the treatment of nasal congestion and minor complications such as allergic rhinitis. However, effectiveness is compromised by the delivery device that provides particles at high velocities leading to early deposition within the nasal vestibule rather than penetrating the nasal valve and depositing onto the main nasal passage walls in the turbinate nasal region. Therefore, studies of nasal-sprayed particles and their deposition are important for improving the efficacy of nasal drug delivery.

Commercially available nasal spray devices deposit most of the atomized drug in the anterior or front portion of the nose, missing the nasal mucosa in the turbinate or middle regions. Understanding deposition of atomized droplets within the main nasal passage provides insight into effective nasal spray targeted delivery.

Droplet Size

Droplet Size Distribution testing of the NNSTS using the Spraytec laser diffractometer  

Using the laser diffractometer droplet diameters of interest were investigated at 3 and 6cm from the nozzle tip. The spray was analyzed for 500ms and the results averaged over that time period

The Perfect Droplet Size

The NasoNeb System creates perfectly sized droplets that get past the front of your nose, and stick to those deep, hard-to-reach areas.

These solution droplets do the work for you, clearing out dust and allergens, reducing inflammation, or breaking down thick and crusty mucous making it easy to gently blow them out.

Drug Deposition

Drug deposition data of common budesonide drug preparations using the nasal model 

Similar results to the chemical assay can be seen visually as the bulk of the deposition occurs in the middle segment of the model using the clear version of the model with Sargel.

NasoNeb Sinus Therapy System Delivery

Representative Images of the Transparent Model Following Budesonide Delivery via the NNSTS

Traditional Spray Pump Delivery

Representative Images of the Transparent Model Following Budesonide Delivery via a Traditional Spray Pump

References

1. Guidance for Industry. Nasal spray and inhalation solution, suspension, and spray drug products. Chemistry, manufacturing and controls documentation. Rockville, MD: US Department of Health and Human Services, Food and Drug Administration, Centre for Drug Evaluation and Research (CDER); 2002.

2. Cheng, Y.S., H.C. Yeh, R.A. Guilmette, S.Q. Simpson, K.H. Cheng, and D.L. Swift. 1996. Nasal deposition of ultrafine particles in human volunteers and its relationship to airway geometry. Aerosol Sci. Technol. 25:274–291.

3. Guilmette, R. A., and T. J. Gagliano. "Construction of a model of human nasal airways using in vivo morphometric data." The Annals of Occupational Hygiene 38, no. VII (1994): 69-75.

4. Cheng, Y. S., T. D. Holmes, J. Gao, R. A. Guilmette, S. Li, Y. Surakitbanharn, and C. Rowlings. "Characterization of nasal spray pumps and deposition pattern in a replica of the human nasal airway." Journal of Aerosol Medicine 14, no. 2 (2001): 267-280.

5. Kulkarni V., Shaw C. Formulation and characterization of nasal sprays. An examination of nasal spray formulation parameters and excipients and their influence on key in vitro tests. Inhalation. 2012:10–15.

6. Sangolkar, S., V. Adhao, D. Mundhe, and H. Sawarkar. "Particle size determination of nasal drug delivery system: A review." Int. J. Pharm. Sci. Rev. Res 17 (2012): 66-73.

7. Xi, Jinxiang, Jiayao Eddie Yuan, Yu Zhang, Dannielle Nevorski, Zhaoxuan Wang, and Yue Zhou. "Visualization and quantification of nasal and olfactory deposition in a sectional adult nasal airway cast." Pharmaceutical research 33, no. 6 (2016): 1527-1541.

8. Xi, Jinxiang, Zhaoxuan Wang, Xiuhua April Si, and Yue Zhou. "Nasal dilation effects on olfactory deposition in unilateral and bi-directional deliveries: In vitro tests and numerical modeling." European Journal of Pharmaceutical Sciences 118 (2018): 113-123.

Meet the Expert

Mark Nagel is the Head of Aerosol Science at Trudell Medical International, has more than 25 years experience in the design, development and testing of aerosol drug delivery devices and has contributed to over 130 publications. He is the inventor on numerous patents and is a co-chair of the New Device and Emerging Therapies E-Health networking group within the International Society for Aerosols in Medicine (ISAM).

Delivery Matters

Evidence shows high viral load is found in the nasal cavity and nasopharynx for viruses and bacteria causing illness. 

Methodology

Laser Diffraction Particle Sizing

The importance of controlling the particle size of nasal sprays has led the U.S. Food and Drug Administration (FDA) to recommend that laser diffraction droplet sizing be carried out for all NDAs and ANDAs for nasal drug delivery systems (1).

Nasal Model

The nasal replica was based on a MRI dataset initially reported in 1994 by Guilmette (3) and has been multiples times since then in particle deposition simulations and experiments for the Lovelace Research Institute of Albuquerque New Mexico. The MRI scans are that of a of a 53-year-old healthy male with no history of nasal abnormalities.

Sinus Therapy System - Starter Kit
Sinus Therapy System - Starter Kit
Sinus Therapy System - Starter Kit
Sinus Therapy System - Starter Kit
Sinus Therapy System - Starter Kit
Sinus Therapy System - Starter Kit
Sinus Therapy System - Starter Kit
Sinus Therapy System - Starter Kit

Sinus Therapy System - Starter Kit

$74.99

Where to buy

Purchase online from our Authorized Partners:

Available at these, and other fine retailers and pharmacies:

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Sinus Therapy System - Starter Kit
Sinus Therapy System - Starter Kit
Sinus Therapy System - Starter Kit
Sinus Therapy System - Starter Kit
Sinus Therapy System - Starter Kit
Sinus Therapy System - Starter Kit
Sinus Therapy System - Starter Kit
Sinus Therapy System - Starter Kit

Sinus Therapy System - Starter Kit

$74.99

Where to buy

Purchase online from our Authorized Partners:

Available at these, and other fine retailers and pharmacies:

Store Locator

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